{"id":20339,"date":"2019-04-01T10:01:57","date_gmt":"2019-04-01T10:01:57","guid":{"rendered":"https:\/\/positivelysharing.wordpress.com\/?p=20339"},"modified":"2019-04-01T10:01:57","modified_gmt":"2019-04-01T10:01:57","slug":"modeling-the-effects-of-morphine-altered-virus-specific-antibody-responses-on-hiv-siv-dynamics","status":"publish","type":"post","link":"https:\/\/positivelysharing.org\/blog\/2019\/04\/01\/modeling-the-effects-of-morphine-altered-virus-specific-antibody-responses-on-hiv-siv-dynamics\/","title":{"rendered":"Modeling the Effects of Morphine-Altered Virus Specific Antibody Responses on HIV\/SIV Dynamics"},"content":{"rendered":"<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading Time: <\/span> <span class=\"rt-time\"> &lt; 1<\/span> <span class=\"rt-label rt-postfix\">minute<\/span><\/span><div class=\"inline-block max-width\"><a class=\"block small-space-below\" href=\"https:\/\/www.nature.com\/articles\/s41598-019-41751-8\/figures\/1\" rel=\"nofollow\"><img decoding=\"async\" class=\"max-width\" src=\"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41598-019-41751-8\/MediaObjects\/41598_2019_41751_Fig1_HTML.png\" alt=\"Figure 1\" aria-describedby=\"figure-1-desc\" \/><\/a><\/div>\n<div id=\"figure-1-desc\" class=\"text14 suppress-bottom-margin add-top-margin sans-serif\">\n<p>Schematics diagram of the model. Uninfected CD4<sup>+<\/sup> T cells: <i>T<\/i><sub><i>l<\/i><\/sub> (target cells with lower susceptibility to infection) and <i>T<\/i><sub><i>h<\/i><\/sub> (target cells with higher susceptibility to infection); infected cells: <i>I<\/i>; free virus: <i>V<\/i>; virus-specific antibody responses: <i>A<\/i>; target cells generation rate: <i>\u03bb<\/i>; death rate of uninfected cells: <i>d<\/i>; infection rates: <i>\u03b2<\/i><sub><i>l<\/i><\/sub> and <i>\u03b2<\/i><sub><i>h<\/i><\/sub>; infected cells death rate: <i>\u03b4<\/i>; virus production rate: <i>p<\/i>; virus\u00a0clearance rate: <i>c<\/i>; transition rates: <i>r<\/i> and <i>q<\/i> from <i>T<\/i><sub><i>l<\/i><\/sub> to <i>T<\/i><sub><i>h<\/i><\/sub> and\u00a0<i>T<\/i><sub><i>h<\/i><\/sub> to <i>T<\/i><sub><i>l<\/i><\/sub>, respectively; efficacy of virus neutralization:\u00a0<i>\u03b5<\/i><sub><i>A<\/i><\/sub>; enhanced virus clearance rate: <i>\u03c3A<\/i>(<i>t<\/i>); and destruction of infected cells rate: <i>\u03b3A<\/i>(<i>t<\/i>).<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p><span style=\"display:inline !important;float:none;background-color:transparent;color:#222222;font-family:'Lora', Palatino, Times, 'Times New Roman', serif;font-size:17px;font-style:normal;font-variant:normal;font-weight:400;letter-spacing:.17px;orphans:2;text-align:left;text-decoration:none;text-indent:0;text-transform:none;white-space:normal;word-spacing:0;word-wrap:break-word;\">Drugs of abuse, such as opiates, have been widely associated with enhancing HIV replication, accelerating disease progression and diminishing host-immune responses, thereby making it harder to effectively manage HIV infection. <a href=\"https:\/\/www.nature.com\/articles\/s41598-019-41751-8\">Read More<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p><span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading Time: <\/span> <span class=\"rt-time\"> &lt; 1<\/span> <span class=\"rt-label rt-postfix\">minute<\/span><\/span>Schematics diagram of the model. Uninfected CD4+ T cells: Tl (target cells with lower susceptibility to infection) and Th (target cells with&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":{"0":"post-20339","1":"post","2":"type-post","3":"status-publish","4":"format-standard","6":"category-hiv"},"jetpack_featured_media_url":"","amp_enabled":true,"_links":{"self":[{"href":"https:\/\/positivelysharing.org\/blog\/wp-json\/wp\/v2\/posts\/20339","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/positivelysharing.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/positivelysharing.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/positivelysharing.org\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/positivelysharing.org\/blog\/wp-json\/wp\/v2\/comments?post=20339"}],"version-history":[{"count":0,"href":"https:\/\/positivelysharing.org\/blog\/wp-json\/wp\/v2\/posts\/20339\/revisions"}],"wp:attachment":[{"href":"https:\/\/positivelysharing.org\/blog\/wp-json\/wp\/v2\/media?parent=20339"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/positivelysharing.org\/blog\/wp-json\/wp\/v2\/categories?post=20339"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/positivelysharing.org\/blog\/wp-json\/wp\/v2\/tags?post=20339"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}